4OF5

Refinement of RAGE-DNA complex in 3S59 without DNA

4OF5 の概要

• エントリーDOI: 10.2210/pdb4of5/pdb
• 分子名称: Advanced glycosylation end product-specific receptor (1 entity in total)
• 機能のキーワード: membrane, signaling proteinig domain, receptor, s100 proteins ab oligomer age dna, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 10: Cell membrane ; Single-pass type I membrane protein : Q15109
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48391.16

構造登録者

Yatime, L.,Andersen, G.R. (登録日: 2014-01-14, 公開日: 2014-04-23, 最終更新日: 2025-03-12)

主引用文献

Yatime, L.,Andersen, G.R.
The specificity of DNA recognition by the RAGE receptor.
J.Exp.Med., 211:749-750, 2014

PubMed Abstract: A recent paper by Sirois et al. in The Journal of Experimental Medicine reports that the receptor for advanced glycation end-products (RAGE) promotes uptake of DNA into endosomes and lowers the immune recognition threshold for the activation of Toll-like receptor 9. Two crystal structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-defined interactions. However, the electron densities for the DNA molecules are weak enough that the presented modeling of DNA is questionable, and models only containing RAGE account for the observed diffraction data just as well as the RAGE-DNA complexes presented by the authors.

PubMed: 24778420
DOI: 10.1084/jem.20132526

実験手法

X-RAY DIFFRACTION (2.803 Å)