4OEL

Crystal structure of Cathepsin C in complex with dipeptide substrates

Summary for 4OEL

• Entry DOI: 10.2210/pdb4oel/pdb
• Related: 4OEM
• Descriptor: Dipeptidyl peptidase 1 Heavy chain, Dipeptidyl peptidase 1 Light chain, SERINE, ... (7 entities in total)
• Functional Keywords: beta barrel, dipeptidyl aminopeptidase i, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 50735.30

Authors

Zhao, B.,Smallwood, A.,Concha, N. (deposition date: 2014-01-13, release date: 2015-03-25, Last modification date: 2020-07-29)

• Primary citation: Rubach, J.K.,Cui, G.,Schneck, J.L.,Taylor, A.N.,Zhao, B.,Smallwood, A.,Nevins, N.,Wisnoski, D.,Thrall, S.H.,Meek, T.D.; The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.; Biochemistry, 51:7551-7568, 2012; PubMed: 22928782; DOI: 10.1021/bi300719b

Experimental method

X-RAY DIFFRACTION (1.4 Å)