4OC5

X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CHIBzL, a urea-based inhibitor N~2~-{[(S)-carboxy(4-hydroxyphenyl)methyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine

4OC5 の概要

• エントリーDOI: 10.2210/pdb4oc5/pdb
• 関連するPDBエントリー: 4OC0 4OC1 4OC2 4OC3 4OC4
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83320.23

構造登録者

Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.,Lubkowski, J.,Barinka, C. (登録日: 2014-01-08, 公開日: 2014-05-21, 最終更新日: 2020-07-29)

• 主引用文献: Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.G.,Lubkowski, J.,Barinka, C.; Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II.; Bioorg.Med.Chem.Lett., 24:2340-2345, 2014; PubMed: 24731280; DOI: 10.1016/j.bmcl.2014.03.066

実験手法

X-RAY DIFFRACTION (1.7 Å)