4OA7
Crystal structure of Tankyrase1 in complex with IWR1
Summary for 4OA7
Entry DOI | 10.2210/pdb4oa7/pdb |
Descriptor | Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, ... (4 entities in total) |
Functional Keywords | tankyrase, inhibitor, iwr1, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 4 |
Total formula weight | 100046.89 |
Authors | |
Primary citation | Kulak, O.,Chen, H.,Holohan, B.,Wu, X.,He, H.,Borek, D.,Otwinowski, Z.,Yamaguchi, K.,Garofalo, L.A.,Ma, Z.,Wright, W.,Chen, C.,Shay, J.W.,Zhang, X.,Lum, L. Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol.Cell.Biol., 35:2425-2435, 2015 Cited by PubMed: 25939383DOI: 10.1128/MCB.00392-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.301 Å) |
Structure validation
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