4OA7
Crystal structure of Tankyrase1 in complex with IWR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tankyrase-1 | polymer | 215 | 24536.9 | 4 | UniProt (O95271) Pfam (PF00644) | Homo sapiens (human) | TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, ARTD5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I |
| 2 | E, G, I, K (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, H, J, L (A, B, C, D) | 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide | non-polymer | 409.4 | 4 | Chemie (2XS) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1105 - 1313 (UniProt: O95271)
| PDB | External Database | Details |
|---|---|---|
| Gly 1099 | - | expression tag |
| Pro 1100 | - | expression tag |
| His 1101 | - | expression tag |
| Met 1102 | - | expression tag |
| Ala 1103 | - | expression tag |
| Ser 1104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98147.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1899.4 | |
| All* | Total formula weight | 100046.9 |
