4O9H

Structure of Interleukin-6 in complex with a Camelid Fab fragment

4O9H の概要

• エントリーDOI: 10.2210/pdb4o9h/pdb
• 分子名称: Interleukin-6, Heavy Chain of the Camelid Fab fragment 61H7, Light Chain of the Camelid Fab fragment 61H7, ... (4 entities in total)
• 機能のキーワード: il6: all alpha protein, fab: all beta protein, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P05231
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67171.20

構造登録者

Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C. (登録日: 2014-01-02, 公開日: 2015-04-15, 最終更新日: 2024-10-30)

• 主引用文献: Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-Rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C.; Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies; To be Published,

実験手法

X-RAY DIFFRACTION (2.42 Å)