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4O7U

Etherocomplex of Enteroccocus faecalis thymidylate synthase with 5-hydroxymethilene-6-hydrofolic acid and the phtalimidic inhibitor SS7

Summary for 4O7U
Entry DOI10.2210/pdb4o7u/pdb
Related3UWL
DescriptorThymidylate synthase, SULFATE ION, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, ... (6 entities in total)
Functional Keywordstransferase, folate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceEnterococcus faecalis
Cellular locationCytoplasm : Q834R3
Total number of polymer chains4
Total formula weight146893.13
Authors
Mangani, S.,Pozzi, C. (deposition date: 2013-12-26, release date: 2014-12-31, Last modification date: 2024-02-28)
Primary citationCatalano, A.,Luciani, R.,Carocci, A.,Cortesi, D.,Pozzi, C.,Borsari, C.,Ferrari, S.,Mangani, S.
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.
Eur.J.Med.Chem., 123:649-664, 2016
Cited by
PubMed: 27517810
DOI: 10.1016/j.ejmech.2016.07.066
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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