4O7U
Etherocomplex of Enteroccocus faecalis thymidylate synthase with 5-hydroxymethilene-6-hydrofolic acid and the phtalimidic inhibitor SS7
Summary for 4O7U
Entry DOI | 10.2210/pdb4o7u/pdb |
Related | 3UWL |
Descriptor | Thymidylate synthase, SULFATE ION, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, ... (6 entities in total) |
Functional Keywords | transferase, folate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Enterococcus faecalis |
Cellular location | Cytoplasm : Q834R3 |
Total number of polymer chains | 4 |
Total formula weight | 146893.13 |
Authors | Mangani, S.,Pozzi, C. (deposition date: 2013-12-26, release date: 2014-12-31, Last modification date: 2024-02-28) |
Primary citation | Catalano, A.,Luciani, R.,Carocci, A.,Cortesi, D.,Pozzi, C.,Borsari, C.,Ferrari, S.,Mangani, S. X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors. Eur.J.Med.Chem., 123:649-664, 2016 Cited by PubMed: 27517810DOI: 10.1016/j.ejmech.2016.07.066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report