4O6I

2.0A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain

4O6I の概要

• エントリーDOI: 10.2210/pdb4o6i/pdb
• 関連するPDBエントリー: 4O6H
• 分子名称: Nucleoprotein, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: exoribonuclease, ribonucleoprotein, hydrolase
• 由来する生物種: Lymphocytic choriomeningitis virus (LCMV)
• 細胞内の位置: Virion: P09992
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53670.57

構造登録者

West, B.R.,Hastie, K.M.,Saphire, E.O. (登録日: 2013-12-20, 公開日: 2014-06-11, 最終更新日: 2023-09-20)

主引用文献

West, B.R.,Hastie, K.M.,Saphire, E.O.
Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.
Acta Crystallogr.,Sect.D, 70:1764-1769, 2014

PubMed Abstract: The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.

PubMed: 24914986
DOI: 10.1107/S1399004714007883

実験手法

X-RAY DIFFRACTION (2 Å)