4O6F

Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2

4O6F の概要

• エントリーDOI: 10.2210/pdb4o6f/pdb
• 分子名称: N-lysine methyltransferase SMYD2, Estrogen receptor, ZINC ION, ... (7 entities in total)
• 機能のキーワード: histone methyltransferase, smyd2, estrogen receptor er alpha, methylation, estrogen signaling, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytosol (By similarity): Q9NRG4; Isoform 1: Nucleus. Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52273.31

構造登録者

Jiang, Y.,Trescott, L.,Holcomb, J.,Brunzelle, J.,Sirinupong, N.,Shi, X.,Yang, Z. (登録日: 2013-12-20, 公開日: 2014-03-26, 最終更新日: 2023-09-20)

• 主引用文献: Jiang, Y.,Trescott, L.,Holcomb, J.,Zhang, X.,Brunzelle, J.,Sirinupong, N.,Shi, X.,Yang, Z.; Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation.; J.Mol.Biol., 426:3413-3425, 2014; PubMed: 24594358; DOI: 10.1016/j.jmb.2014.02.019

実験手法

X-RAY DIFFRACTION (2.822 Å)