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4O3R

Crystal structure of human polymerase eta extending an 8-oxog dna lesion: post insertion of 8-oxog-da pair

Summary for 4O3R
Entry DOI10.2210/pdb4o3r/pdb
Related4O3N 4O3O 4O3P 4O3Q 4O3S
DescriptorDNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(8OG)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... (7 entities in total)
Functional Keywordscatalytic domain, dna, dna damage, dna-directed dna polymerase, cytosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, 8-oxog lesion bypass, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: Q9Y253
Total number of polymer chains3
Total formula weight55446.71
Authors
Patra, A.,Egli, M. (deposition date: 2013-12-18, release date: 2014-04-30, Last modification date: 2023-09-20)
Primary citationPatra, A.,Nagy, L.D.,Zhang, Q.,Su, Y.,Muller, L.,Guengerich, F.P.,Egli, M.
Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289:16867-16882, 2014
Cited by
PubMed: 24759104
DOI: 10.1074/jbc.M114.551820
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.62 Å)
Structure validation

217705

数据于2024-03-27公开中

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