4O1Z

Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam

Summary for 4O1Z

Entry DOI	10.2210/pdb4o1z/pdb
Related	1DIY 1Q4G 4M11
Descriptor	Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywords	dioxygenase, peroxidase, nsaids, glycosylation, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Ovis aries (domestic sheep,lambs,wild sheep)
Total number of polymer chains	2
Total formula weight	135246.22
Authors	Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. (deposition date: 2013-12-16, release date: 2014-01-22, Last modification date: 2023-09-20)
Primary citation	Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J.Biol.Chem., 289:6799-6808, 2014 Cited by PubMed: 24425867 DOI: 10.1074/jbc.M113.517987 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation