4O1Z

Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam

4O1Z の概要

• エントリーDOI: 10.2210/pdb4o1z/pdb
• 関連するPDBエントリー: 1DIY 1Q4G 4M11
• 分子名称: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• 機能のキーワード: dioxygenase, peroxidase, nsaids, glycosylation, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Ovis aries (domestic sheep,lambs,wild sheep)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 135246.22

構造登録者

Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. (登録日: 2013-12-16, 公開日: 2014-01-22, 最終更新日: 2023-09-20)

• 主引用文献: Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J.; Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.; J.Biol.Chem., 289:6799-6808, 2014; PubMed: 24425867; DOI: 10.1074/jbc.M113.517987

実験手法

X-RAY DIFFRACTION (2.4 Å)