4O1V

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

4O1V の概要

• エントリーDOI: 10.2210/pdb4o1v/pdb
• 分子名称: Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (3 entities in total)
• 機能のキーワード: ubl conjugation pathway, ligase, ubiquitin, e3, spop, math, pten, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: O43791; Cytoplasm: P60484
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 18019.44

構造登録者

Calabrese, M.F.,Watson, E.R.,Schulman, B.A. (登録日: 2013-12-16, 公開日: 2014-04-30, 最終更新日: 2023-09-20)

• 主引用文献: Li, G.,Ci, W.,Karmakar, S.,Chen, K.,Dhar, R.,Fan, Z.,Guo, Z.,Zhang, J.,Ke, Y.,Wang, L.,Zhuang, M.,Hu, S.,Li, X.,Zhou, L.,Li, X.,Calabrese, M.F.,Watson, E.R.,Prasad, S.M.,Rinker-Schaeffer, C.,Eggener, S.E.,Stricker, T.,Tian, Y.,Schulman, B.A.,Liu, J.,White, K.P.; SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.; Cancer Cell, 25:455-468, 2014; PubMed: 24656772; DOI: 10.1016/j.ccr.2014.02.007

実験手法

X-RAY DIFFRACTION (2 Å)