4O1L
Human Adenosine Kinase in complex with inhibitor
Summary for 4O1L
Entry DOI | 10.2210/pdb4o1l/pdb |
Related | 4PVV |
Descriptor | Adenosine kinase, MAGNESIUM ION, 5-ethynyl-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total) |
Functional Keywords | adenosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 2: Cytoplasm: P55263 |
Total number of polymer chains | 2 |
Total formula weight | 78602.58 |
Authors | Brynda, J.,Dostal, J.,Pichova, I.,Hodcek, M. (deposition date: 2013-12-16, release date: 2014-11-26, Last modification date: 2024-03-20) |
Primary citation | Snasel, J.,Naus, P.,Dostal, J.,Hnizda, A.,Fanfrlik, J.,Brynda, J.,Bourderioux, A.,Dusek, M.,Dvorakova, H.,Stolarikova, J.,Zabranska, H.,Pohl, R.,Konecny, P.,Dzubak, P.,Votruba, I.,Hajduch, M.,Rezacova, P.,Veverka, V.,Hocek, M.,Pichova, I. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides J.Med.Chem., 57:8268-8279, 2014 Cited by PubMed: 25259627DOI: 10.1021/jm500497v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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