4O1L
Human Adenosine Kinase in complex with inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0004001 | molecular_function | adenosine kinase activity |
A | 0004136 | molecular_function | deoxyadenosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006144 | biological_process | purine nucleobase metabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006175 | biological_process | dATP biosynthetic process |
A | 0006753 | biological_process | nucleoside phosphate metabolic process |
A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0032263 | biological_process | GMP salvage |
A | 0034654 | biological_process | nucleobase-containing compound biosynthetic process |
A | 0044209 | biological_process | AMP salvage |
A | 0046872 | molecular_function | metal ion binding |
A | 0106383 | biological_process | dAMP salvage |
B | 0003723 | molecular_function | RNA binding |
B | 0004001 | molecular_function | adenosine kinase activity |
B | 0004136 | molecular_function | deoxyadenosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006144 | biological_process | purine nucleobase metabolic process |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006175 | biological_process | dATP biosynthetic process |
B | 0006753 | biological_process | nucleoside phosphate metabolic process |
B | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0032263 | biological_process | GMP salvage |
B | 0034654 | biological_process | nucleobase-containing compound biosynthetic process |
B | 0044209 | biological_process | AMP salvage |
B | 0046872 | molecular_function | metal ion binding |
B | 0106383 | biological_process | dAMP salvage |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 401 |
Chain | Residue |
A | GLY13 |
A | ASN14 |
A | THR66 |
A | HO4403 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 402 |
Chain | Residue |
A | HOH506 |
A | HOH507 |
A | HOH508 |
A | HOH509 |
A | HOH510 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HO4 A 403 |
Chain | Residue |
A | ASN14 |
A | LEU16 |
A | ASP18 |
A | ILE39 |
A | LEU40 |
A | GLY63 |
A | GLY64 |
A | SER65 |
A | ASN68 |
A | PHE170 |
A | ASN296 |
A | GLY297 |
A | ASP300 |
A | MG401 |
A | HOH501 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE HO4 A 404 |
Chain | Residue |
A | THR265 |
A | GLY267 |
A | ARG268 |
A | VAL284 |
A | ASP286 |
A | GLN287 |
A | ALA298 |
A | GLY299 |
A | HIS324 |
A | ALA327 |
A | ILE331 |
A | HOH505 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 401 |
Chain | Residue |
B | ASN14 |
B | THR66 |
B | ALA168 |
B | HO4403 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 402 |
Chain | Residue |
B | HOH504 |
B | HOH505 |
B | HOH506 |
B | HOH507 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HO4 B 403 |
Chain | Residue |
B | ASN14 |
B | LEU16 |
B | ASP18 |
B | ILE39 |
B | GLY63 |
B | GLY64 |
B | SER65 |
B | ASN68 |
B | ALA136 |
B | PHE170 |
B | ASN296 |
B | GLY297 |
B | ASP300 |
B | MG401 |
B | HOH508 |
Functional Information from PROSITE/UniProt
site_id | PS00584 |
Number of Residues | 14 |
Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
Chain | Residue | Details |
A | ASP294-LEU307 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9843365, ECO:0007744|PDB:1BX4 |
Chain | Residue | Details |
A | ASP300 | |
B | ASP300 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9843365, ECO:0007744|PDB:1BX4 |
Chain | Residue | Details |
A | ASP18 | |
B | GLN289 | |
A | SER32 | |
A | ASP130 | |
A | ASN131 | |
A | GLN289 | |
B | ASP18 | |
B | SER32 | |
B | ASP130 | |
B | ASN131 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12112843 |
Chain | Residue | Details |
A | TYR60 | |
B | TYR60 |