4O1L
Human Adenosine Kinase in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006170 | biological_process | dAMP biosynthetic process |
| A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032261 | biological_process | purine nucleotide salvage |
| A | 0044209 | biological_process | AMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0110052 | biological_process | toxic metabolite repair |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0004136 | molecular_function | deoxyadenosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006170 | biological_process | dAMP biosynthetic process |
| B | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032261 | biological_process | purine nucleotide salvage |
| B | 0044209 | biological_process | AMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0110052 | biological_process | toxic metabolite repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | GLY13 |
| A | ASN14 |
| A | THR66 |
| A | HO4403 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | HOH506 |
| A | HOH507 |
| A | HOH508 |
| A | HOH509 |
| A | HOH510 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HO4 A 403 |
| Chain | Residue |
| A | ASN14 |
| A | LEU16 |
| A | ASP18 |
| A | ILE39 |
| A | LEU40 |
| A | GLY63 |
| A | GLY64 |
| A | SER65 |
| A | ASN68 |
| A | PHE170 |
| A | ASN296 |
| A | GLY297 |
| A | ASP300 |
| A | MG401 |
| A | HOH501 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HO4 A 404 |
| Chain | Residue |
| A | THR265 |
| A | GLY267 |
| A | ARG268 |
| A | VAL284 |
| A | ASP286 |
| A | GLN287 |
| A | ALA298 |
| A | GLY299 |
| A | HIS324 |
| A | ALA327 |
| A | ILE331 |
| A | HOH505 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASN14 |
| B | THR66 |
| B | ALA168 |
| B | HO4403 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | HOH504 |
| B | HOH505 |
| B | HOH506 |
| B | HOH507 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HO4 B 403 |
| Chain | Residue |
| B | ASN14 |
| B | LEU16 |
| B | ASP18 |
| B | ILE39 |
| B | GLY63 |
| B | GLY64 |
| B | SER65 |
| B | ASN68 |
| B | ALA136 |
| B | PHE170 |
| B | ASN296 |
| B | GLY297 |
| B | ASP300 |
| B | MG401 |
| B | HOH508 |
Functional Information from PROSITE/UniProt
| site_id | PS00584 |
| Number of Residues | 14 |
| Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
| Chain | Residue | Details |
| A | ASP294-LEU307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"12112843","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
