4O0D

Crystal structure of the human L-asparaginase protein T168S mutant

Summary for 4O0D

Entry DOI	10.2210/pdb4o0d/pdb
Related	4O0C 4O0E 4O0F 4O0G 4O0H
Descriptor	Isoaspartyl peptidase/L-asparaginase, SODIUM ION, GLYCINE, ... (4 entities in total)
Functional Keywords	ntn enzyme, homodimer, asparaginase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q7L266
Total number of polymer chains	2
Total formula weight	64783.48
Authors	Nomme, J.,Lavie, A. (deposition date: 2013-12-13, release date: 2014-04-30, Last modification date: 2023-09-20)
Primary citation	Nomme, J.,Su, Y.,Lavie, A. Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis. J.Mol.Biol., 426:2471-2485, 2014 Cited by PubMed: 24768817 DOI: 10.1016/j.jmb.2014.04.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation