4NYG
Crystal structure of the E. coli thiM riboswitch in complex with thiamine
Summary for 4NYG
Entry DOI | 10.2210/pdb4nyg/pdb |
Related | 4NYA 4NYB 4NYC 4NYD |
Descriptor | thiM TPP riboswitch, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | fragment-based drug discovery, riboswitch, rna |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 27272.09 |
Authors | Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R. (deposition date: 2013-12-10, release date: 2014-06-04, Last modification date: 2023-09-20) |
Primary citation | Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R. Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically. Chem.Biol., 21:591-595, 2014 Cited by PubMed: 24768306DOI: 10.1016/j.chembiol.2014.03.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
Download full validation report