4NY8
DNA polymerase beta with O6mG in the template base opposite to incoming non-hydrolyzable CTP with manganese in the active site
Summary for 4NY8
Entry DOI | 10.2210/pdb4ny8/pdb |
Related | 4NXZ |
Descriptor | DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*(6OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ... (8 entities in total) |
Functional Keywords | dna binding, dna polymerase fold, nucleotidyl transfer, nucleolus, transferase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P06746 |
Total number of polymer chains | 4 |
Total formula weight | 47283.67 |
Authors | Koag, M.-C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-12-10, release date: 2014-04-16, Last modification date: 2024-02-28) |
Primary citation | Koag, M.C.,Lee, S. Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136:5709-5721, 2014 Cited by PubMed: 24694247DOI: 10.1021/ja500172d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.246 Å) |
Structure validation
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