4NUS
Rsk2 N-terminal kinase in complex with LJH685
Summary for 4NUS
Entry DOI | 10.2210/pdb4nus/pdb |
Descriptor | Ribosomal protein S6 kinase alpha-3, 2,6-difluoro-4-{4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl}phenol (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P51812 |
Total number of polymer chains | 1 |
Total formula weight | 37586.41 |
Authors | Appleton, B.A. (deposition date: 2013-12-04, release date: 2014-03-05, Last modification date: 2024-02-28) |
Primary citation | Aronchik, I.,Appleton, B.A.,Basham, S.E.,Crawford, K.,Del Rosario, M.,Doyle, L.V.,Estacio, W.F.,Lan, J.,Lindvall, M.K.,Luu, C.A.,Ornelas, E.,Venetsanakos, E.,Shafer, C.M.,Jefferson, A.B. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res, 12:803-812, 2014 Cited by PubMed: 24554780DOI: 10.1158/1541-7786.MCR-13-0595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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