4NUS

Rsk2 N-terminal kinase in complex with LJH685

4NUS の概要

• エントリーDOI: 10.2210/pdb4nus/pdb
• 分子名称: Ribosomal protein S6 kinase alpha-3, 2,6-difluoro-4-{4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl}phenol (3 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P51812
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37586.41

構造登録者

Appleton, B.A. (登録日: 2013-12-04, 公開日: 2014-03-05, 最終更新日: 2024-02-28)

• 主引用文献: Aronchik, I.,Appleton, B.A.,Basham, S.E.,Crawford, K.,Del Rosario, M.,Doyle, L.V.,Estacio, W.F.,Lan, J.,Lindvall, M.K.,Luu, C.A.,Ornelas, E.,Venetsanakos, E.,Shafer, C.M.,Jefferson, A.B.; Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.; Mol Cancer Res, 12:803-812, 2014; PubMed: 24554780; DOI: 10.1158/1541-7786.MCR-13-0595

実験手法

X-RAY DIFFRACTION (2.39 Å)