4NR9
Crystal Structure of the bromodomain of human BAZ2B in complex with acetylated lysine
Summary for 4NR9
| Entry DOI | 10.2210/pdb4nr9/pdb |
| Related | 4NRA 4NRB 4NRC |
| Descriptor | Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, N(6)-ACETYLLYSINE, ... (4 entities in total) |
| Functional Keywords | sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4 |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (Potential): Q9UIF8 |
| Total number of polymer chains | 1 |
| Total formula weight | 14055.15 |
| Authors | Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-25, Last modification date: 2023-12-06) |
| Primary citation | Ferguson, F.M.,Fedorov, O.,Chaikuad, A.,Philpott, M.,Muniz, J.R.,Felletar, I.,von Delft, F.,Heightman, T.,Knapp, S.,Abell, C.,Ciulli, A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56:10183-10187, 2013 Cited by PubMed Abstract: Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful targeting of the challenging BAZ2B bromodomain using biophysical fragment screening and structure-based optimization of high ligand-efficiency fragments into a novel series of low-micromolar inhibitors. Our results provide attractive leads for development of BAZ2B chemical probes and indicate the whole family may be tractable. PubMed: 24304323DOI: 10.1021/jm401582c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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