4NP4

Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab

4NP4 の概要

• エントリーDOI: 10.2210/pdb4np4/pdb
• 分子名称: Toxin B, bezlotoxumab heavy chain, bezlotoxumab light chain, ... (4 entities in total)
• 機能のキーワード: bezlotoxumab, human antibody, fab, crop domain, cytotoxin, short repeat, long repeat, tcdb, receptor binding, immune system
• 由来する生物種: Clostridium difficile; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 126218.78

構造登録者

Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.,Beaumont, M.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G. (登録日: 2013-11-20, 公開日: 2014-05-21, 最終更新日: 2023-09-20)

• 主引用文献: Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.R.,Beaumont, M.,Yang, X.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G.; Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography.; J.Biol.Chem., 289:18008-18021, 2014; PubMed: 24821719; DOI: 10.1074/jbc.M114.560748

実験手法

X-RAY DIFFRACTION (2.89 Å)