4NOL

Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain mutant D233A at pH 7.5

Summary for 4NOL

• Entry DOI: 10.2210/pdb4nol/pdb
• Related: 4NOJ 4NOK 4NOM
• Descriptor: Legumain (2 entities in total)
• Functional Keywords: new fold, asparaginyl endopeptidase, substrate, extracellular, hydrolase
• Biological source: Mus musculus (mouse)
• Cellular location: Lysosome: O89017
• Total number of polymer chains: 2
• Total formula weight: 100445.50

Authors

Zhao, L.,Hua, T.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Ouyang, S.,Liu, Z.J. (deposition date: 2013-11-19, release date: 2014-02-19, Last modification date: 2014-03-19)

• Primary citation: Zhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J.; Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.; Cell Res., 24:344-358, 2014; PubMed: 24407422; DOI: 10.1038/cr.2014.4

Experimental method

X-RAY DIFFRACTION (2.7 Å)