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4NOJ

Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5

Summary for 4NOJ
Entry DOI10.2210/pdb4noj/pdb
Related4NOK 4NOL 4NOM
DescriptorLegumain (2 entities in total)
Functional Keywordsnew fold, asparaginyl endopeptidase, substrate, extracellular, hydrolase
Biological sourceMus musculus (mouse)
Cellular locationLysosome: O89017
Total number of polymer chains1
Total formula weight29981.58
Authors
Zhao, L.,Hua, T.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Ouyang, S.,Liu, Z.J. (deposition date: 2013-11-19, release date: 2014-02-19, Last modification date: 2024-02-28)
Primary citationZhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J.
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24:344-358, 2014
Cited by
PubMed: 24407422
DOI: 10.1038/cr.2014.4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

건을2024-03-27부터공개중

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