4NMX
PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8
Summary for 4NMX
Entry DOI | 10.2210/pdb4nmx/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9, peptide 2-8, ... (4 entities in total) |
Functional Keywords | subtlisin, receptor degradation, ldl receptor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q8NBP7 Q8NBP7 |
Total number of polymer chains | 3 |
Total formula weight | 48542.43 |
Authors | Eigenbrot, C.,Shia, S. (deposition date: 2013-11-15, release date: 2013-12-04, Last modification date: 2023-09-20) |
Primary citation | Zhang, Y.,Eigenbrot, C.,Zhou, L.,Shia, S.,Li, W.,Quan, C.,Tom, J.,Moran, P.,Di Lello, P.,Skelton, N.J.,Kong-Beltran, M.,Peterson, A.,Kirchhofer, D. Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor. J.Biol.Chem., 289:942-955, 2014 Cited by PubMed: 24225950DOI: 10.1074/jbc.M113.514067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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