4NL9

Crystal structure of the human Anks3-SAM/Anks6-SAM heterodimer

4NL9 の概要

• エントリーDOI: 10.2210/pdb4nl9/pdb
• 関連するPDBエントリー: 4NJ8
• 分子名称: Ankyrin repeat and SAM domain-containing protein 3, Ankyrin repeat and SAM domain-containing protein 6, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: sam domain, protein-protein interaction domain, heterodimer, samcystin, polycystic kidney disease, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell projection, cilium (By similarity): Q68DC2
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 31910.29

構造登録者

Leettola, C.N.,Cascio, D.,Bowie, J.U. (登録日: 2013-11-13, 公開日: 2014-07-16, 最終更新日: 2023-09-20)

主引用文献

Leettola, C.N.,Knight, M.J.,Cascio, D.,Hoffman, S.,Bowie, J.U.
Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.
Bmc Struct.Biol., 14:17-17, 2014

PubMed Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the sterile alpha motif (SAM) domain of the protein ANKS6 is responsible for disease. SAM domains are known protein-protein interaction domains, capable of binding each other to form polymers and heterodimers. Despite its physiological importance, little is known about the function of ANKS6 and how the R823W point mutation leads to PKD. Recent work has revealed that ANKS6 interacts with a related protein called ANKS3. Both ANKS6 and ANKS3 have a similar domain structure, with ankyrin repeats at the N-terminus and a SAM domain at the C-terminus.

PubMed: 24998259
DOI: 10.1186/1472-6807-14-17

実験手法

X-RAY DIFFRACTION (1.5 Å)