4NKZ

Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxypregnenolone

4NKZ の概要

• エントリーDOI: 10.2210/pdb4nkz/pdb
• 関連するPDBエントリー: 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY
• 分子名称: Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha)-3,17-dihydroxypregn-5-en-20-one, ... (4 entities in total)
• 機能のキーワード: heme protein, monooxygenase, steroid 17alpha-hydroxylase, steroid c17, 20 lyase, nadph-cytochrome p450 reductase, cytochrome b5, endoplasmic reticulum membrane, oxidoreductase, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane : P05093
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 226924.75

構造登録者

Scott, E.E.,Petrunak, E.M. (登録日: 2013-11-13, 公開日: 2014-10-22, 最終更新日: 2023-09-20)

• 主引用文献: Petrunak, E.M.,DeVore, N.M.,Porubsky, P.R.,Scott, E.E.; Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates.; J.Biol.Chem., 289:32952-32964, 2014; PubMed: 25301938; DOI: 10.1074/jbc.M114.610998

実験手法

X-RAY DIFFRACTION (3.003 Å)