4NK9
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1
Summary for 4NK9
Entry DOI | 10.2210/pdb4nk9/pdb |
Related | 4F63 4F64 4F65 4NKA 4NKS |
Descriptor | FIBROBLAST GROWTH FACTOR RECEPTOR 1, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71678.10 |
Authors | Norman, R.A.,Klein, T. (deposition date: 2013-11-12, release date: 2013-12-18, Last modification date: 2024-02-28) |
Primary citation | Klein, T.,Tucker, J.,Holdgate, G.A.,Norman, R.A.,Breeze, A.L. FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures. ACS Med Chem Lett, 5:166-171, 2014 Cited by PubMed: 24900792DOI: 10.1021/ml4004205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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