4NIO

GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis

4NIO の概要

• エントリーDOI: 10.2210/pdb4nio/pdb
• 関連するPDBエントリー: 4NIN 4NIP
• 分子名称: GVTGIAQ segment from Superoxide dismutase [Cu-Zn] (2 entities in total)
• 機能のキーワード: steric zipper, cross-beta spine, amyloid fiber, protein fibril
• 由来する生物種: Homo Sapiens (human)
• 細胞内の位置: Cytoplasm : P00441
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 644.72

構造登録者

Sievers, S.A.,Sawaya, M.R.,Eisenberg, D.,Ivanova, M.I. (登録日: 2013-11-06, 公開日: 2013-12-04, 最終更新日: 2024-02-28)

• 主引用文献: Ivanova, M.I.,Sievers, S.A.,Guenther, E.L.,Johnson, L.M.,Winkler, D.D.,Galaleldeen, A.,Sawaya, M.R.,Hart, P.J.,Eisenberg, D.S.; Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.; Proc.Natl.Acad.Sci.USA, 111:197-201, 2014; PubMed: 24344300; DOI: 10.1073/pnas.1320786110

実験手法

X-RAY DIFFRACTION (1.3 Å)