4NI2

Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase

4NI2 の概要

• エントリーDOI: 10.2210/pdb4ni2/pdb
• 分子名称: Guanylate cyclase soluble subunit alpha-3, Guanylate cyclase soluble subunit beta-1, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: heterodimeric, lyase, cgmp biosynthesis, nitric oxide, cyclase, gtp-binding, metal-binding, nucleotide binding, cytosol
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : Q02108 Q02153
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45725.72

構造登録者

Seeger, F.,Williams, G.J.,Tainer, J.A.,Garcin, E.D. (登録日: 2013-11-05, 公開日: 2014-04-16, 最終更新日: 2023-09-20)

• 主引用文献: Seeger, F.,Quintyn, R.,Tanimoto, A.,Williams, G.J.,Tainer, J.A.,Wysocki, V.H.,Garcin, E.D.; Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.; Biochemistry, 53:2153-2165, 2014; PubMed: 24669844; DOI: 10.1021/bi500129k

実験手法

X-RAY DIFFRACTION (1.9 Å)