4NH9

Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity

4NH9 の概要

• エントリーDOI: 10.2210/pdb4nh9/pdb
• 関連するPDBエントリー: 4NH7 4NH8
• 分子名称: Endoplasmin, 2-fluoro-6-[(3S)-tetrahydrofuran-3-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (2 entities in total)
• 機能のキーワード: a/b structure, chaperone, endoplasmic reticulum
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum lumen: P14625
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31485.28

構造登録者

Zuccola, H.J.,Ernst, J.T. (登録日: 2013-11-04, 公開日: 2014-01-22, 最終更新日: 2024-02-28)

• 主引用文献: Ernst, J.T.,Liu, M.,Zuccola, H.,Neubert, T.,Beaumont, K.,Turnbull, A.,Kallel, A.,Vought, B.,Stamos, D.; Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases.; Bioorg.Med.Chem.Lett., 24:204-208, 2014; PubMed: 24332488; DOI: 10.1016/j.bmcl.2013.11.036

実験手法

X-RAY DIFFRACTION (2.77 Å)