4NH9
Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoplasmin | polymer | 273 | 31085.8 | 1 | UniProt (P14625) Pfam (PF13589) | Homo sapiens (human) | 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog |
| 2 | B (A) | 2-fluoro-6-[(3S)-tetrahydrofuran-3-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide | non-polymer | 399.5 | 1 | Chemie (2LC) |
Sequence modifications
A: 69 - 337 (UniProt: P14625)
| PDB | External Database | Details |
|---|---|---|
| Gly 65 | - | expression tag |
| Ser 66 | - | expression tag |
| His 67 | - | expression tag |
| Met 68 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31085.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 399.5 | |
| All* | Total formula weight | 31485.3 |
