4NH8

Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity

Summary for 4NH8

Entry DOI	10.2210/pdb4nh8/pdb
Related	4NH7
Descriptor	Heat shock protein HSP 90-alpha, 2-fluoro-6-[(3S)-tetrahydrofuran-3-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (3 entities in total)
Functional Keywords	a/b protein, chaperone
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P07900
Total number of polymer chains	1
Total formula weight	26582.86
Authors	Ernst, J.T.,Zuccola, H.J. (deposition date: 2013-11-04, release date: 2014-01-15, Last modification date: 2024-02-28)
Primary citation	Ernst, J.T.,Liu, M.,Zuccola, H.,Neubert, T.,Beaumont, K.,Turnbull, A.,Kallel, A.,Vought, B.,Stamos, D. Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases. Bioorg.Med.Chem.Lett., 24:204-208, 2014 Cited by PubMed: 24332488 DOI: 10.1016/j.bmcl.2013.11.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation