4NFR
Human brain aspartoacylase mutant E285A complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Summary for 4NFR
Entry DOI | 10.2210/pdb4nfr/pdb |
Related | 2o4h 2o53 |
Descriptor | Aspartoacylase, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ZINC ION, ... (4 entities in total) |
Functional Keywords | canavan disease, n-acetyl-l-aspartate, zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P45381 |
Total number of polymer chains | 2 |
Total formula weight | 72005.13 |
Authors | Wijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E. (deposition date: 2013-10-31, release date: 2014-07-30, Last modification date: 2023-09-20) |
Primary citation | Wijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E. Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective. Biochemistry, 53:4970-4978, 2014 Cited by PubMed: 25003821DOI: 10.1021/bi500719k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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