4NFL

Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor NPB-T

Summary for 4NFL

Entry DOI	10.2210/pdb4nfl/pdb
Related	4L6C 4MWO
Descriptor	5'(3')-deoxyribonucleotidase, mitochondrial, MAGNESIUM ION, PHOSPHATE ION, ... (8 entities in total)
Functional Keywords	had-like, nucleotidase, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion: Q9NPB1
Total number of polymer chains	1
Total formula weight	25252.62
Authors	Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2013-10-31, release date: 2014-09-10, Last modification date: 2023-09-20)
Primary citation	Simak, O.,Pachl, P.,Fabry, M.,Budesinsky, M.,Jandusik, T.,Hnizda, A.,Sklenickova, R.,Petrova, M.,Veverka, V.,Rezacova, P.,Brynda, J.,Rosenberg, I. Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases. Org.Biomol.Chem., 12:7971-7982, 2014 Cited by PubMed: 25178098 DOI: 10.1039/c4ob01332h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.375 Å)

Structure validation