4NCX

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum 3D7

4NCX の概要

• エントリーDOI: 10.2210/pdb4ncx/pdb
• 分子名称: Proline--tRNA ligase, 1,2-ETHANEDIOL, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, ligase, prolyl-trna synthetase
• 由来する生物種: Plasmodium falciparum 3D7
• 細胞内の位置: Cytoplasm : Q8I5R7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 118451.76

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2013-10-25, 公開日: 2014-10-29, 最終更新日: 2023-09-20)

• 主引用文献: Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C.; Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.; Acs Infect Dis., 3:34-44, 2017; PubMed: 27798837; DOI: 10.1021/acsinfecdis.6b00078

実験手法

X-RAY DIFFRACTION (1.85 Å)