4NAU

S. aureus CoaD with Inhibitor

Summary for 4NAU

• Entry DOI: 10.2210/pdb4nau/pdb
• Related: 4NAH 4NAT
• Descriptor: Phosphopantetheine adenylyltransferase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, 2-[2-[(1S,2S)-2-[(3,4-dichlorophenyl)methylcarbamoyl]cyclohexyl]-6-ethyl-pyrimidin-4-yl]-4-oxidanyl-6-oxidanylidene-1H-pyrimidine-5-carboxamide, ... (4 entities in total)
• Functional Keywords: phosphopanthetheine adenylyltransferase, coabc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus
• Cellular location: Cytoplasm : P63820
• Total number of polymer chains: 3
• Total formula weight: 57306.63

Authors

Lahiri, S.D. (deposition date: 2013-10-22, release date: 2014-03-12, Last modification date: 2024-02-28)

• Primary citation: de Jonge, B.L.,Walkup, G.K.,Lahiri, S.D.,Huynh, H.,Neckermann, G.,Utley, L.,Nash, T.J.,Brock, J.,San Martin, M.,Kutschke, A.,Johnstone, M.,Laganas, V.,Hajec, L.,Gu, R.F.,Ni, H.,Chen, B.,Hutchings, K.,Holt, E.,McKinney, D.,Gao, N.,Livchak, S.,Thresher, J.; Discovery of Inhibitors of 4'-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy.; Antimicrob.Agents Chemother., 57:6005-6015, 2013; PubMed: 24041904; DOI: 10.1128/AAC.01661-13

Experimental method

X-RAY DIFFRACTION (2.33 Å)