4N8E

DPP4 complexed with compound 12a

Summary for 4N8E

• Entry DOI: 10.2210/pdb4n8e/pdb
• Related: 4N8D 4a5s
• Descriptor: Dipeptidyl peptidase 4, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 176445.72

Authors

Ostermann, N.,Zink, F.,Kroemer, M. (deposition date: 2013-10-17, release date: 2014-02-12, Last modification date: 2020-07-29)

• Primary citation: Namoto, K.,Sirockin, F.,Ostermann, N.,Gessier, F.,Flohr, S.,Sedrani, R.,Gerhartz, B.,Trappe, J.,Hassiepen, U.,Duttaroy, A.,Ferreira, S.,Sutton, J.M.,Clark, D.E.,Fenton, G.,Beswick, M.,Baeschlin, D.K.; Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.; Bioorg.Med.Chem.Lett., 24:731-736, 2014; PubMed: 24439847; DOI: 10.1016/j.bmcl.2013.12.118

Experimental method

X-RAY DIFFRACTION (2.3 Å)