4N4W
Structure of the human smoothened receptor in complex with SANT-1.
Summary for 4N4W
Entry DOI | 10.2210/pdb4n4w/pdb |
Related | 4JKV |
Descriptor | Cytochrome b(562),Smoothened homolog, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, ... (8 entities in total) |
Functional Keywords | human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, transport protein |
Biological source | Shigella flexneri 5 str. 8401 More |
Total number of polymer chains | 1 |
Total formula weight | 55387.42 |
Authors | Wang, C.,Wu, H.,Han, G.W.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2013-10-08, release date: 2014-01-22, Last modification date: 2023-09-20) |
Primary citation | Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5:4355-4355, 2014 Cited by PubMed: 25008467DOI: 10.1038/ncomms5355 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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