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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4N4W

Structure of the human smoothened receptor in complex with SANT-1.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005506molecular_functioniron ion binding
A0007166biological_processcell surface receptor signaling pathway
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0042597cellular_componentperiplasmic space
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI5
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues29
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues50
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27437577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28513578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L7D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XBM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32929279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31168089","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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