4N1Z

Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222

Summary for 4N1Z

• Entry DOI: 10.2210/pdb4n1z/pdb
• Related: 4GA3
• Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: alpha fold, synthase, ionization, dephosphorylation, cytosol, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 40676.85

Authors

Liu, Y.L.,Xia, Y.,Zhang, Y.,Verma, I.,Oldfield, E. (deposition date: 2013-10-04, release date: 2014-12-10, Last modification date: 2023-09-20)

• Primary citation: Xia, Y.,Liu, Y.L.,Xie, Y.,Zhu, W.,Guerra, F.,Shen, S.,Yeddula, N.,Fischer, W.,Low, W.,Zhou, X.,Zhang, Y.,Oldfield, E.,Verma, I.M.; A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.; Sci Transl Med, 6:263ra161-263ra161, 2014; PubMed: 25411474; DOI: 10.1126/scitranslmed.3010382

Experimental method

X-RAY DIFFRACTION (2.35 Å)