4MXO

human Src kinase bound to kinase inhibitor bosutinib

Summary for 4MXO

Entry DOI	10.2210/pdb4mxo/pdb
Related	4MXX 4MXY 4MXZ
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (3 entities in total)
Functional Keywords	kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	2
Total formula weight	66482.06
Authors	Levinson, N.M.,Boxer, S.G. (deposition date: 2013-09-26, release date: 2013-12-04, Last modification date: 2024-02-28)
Primary citation	Levinson, N.M.,Boxer, S.G. A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity. Nat.Chem.Biol., 10:127-132, 2014 Cited by PubMed: 24292070 DOI: 10.1038/nchembio.1404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.105 Å)

Structure validation