4MW6

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[2-(benzyloxy)-5-chloro-3-(prop-2-en-1-yl)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1476)

4MW6 の概要

• エントリーDOI: 10.2210/pdb4mw6/pdb
• 関連するPDBエントリー: 4EG1 4EG3 4EG5 4MVW 4MVX 4MVY 4MW0 4MW1 4MW2 4MW4 4MW5 4MW7 4MW9 4MWB 4MWC 4MWD 4MWE
• 分子名称: Methionyl-tRNA synthetase, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, aars, metrs, parasite, protein-inhibitor complex, rossmann fold, translation, nucleotide binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 124930.08

構造登録者

Koh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Liu, J.,Zhang, Z.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (登録日: 2013-09-24, 公開日: 2014-04-30, 最終更新日: 2023-09-20)

• 主引用文献: Koh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Ranade, R.M.,Liu, J.,Zhang, Z.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.; Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.; Plos Negl Trop Dis, 8:e2775-e2775, 2014; PubMed: 24743796; DOI: 10.1371/journal.pntd.0002775

実験手法

X-RAY DIFFRACTION (2.558 Å)