4MVL

Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40

4MVL の概要

• エントリーDOI: 10.2210/pdb4mvl/pdb
• 関連するPDBエントリー: 4MVI 4MVK
• 分子名称: Neutrophil gelatinase-associated lipocalin, Beta-amyloid protein 40 (3 entities in total)
• 機能のキーワード: beta-barrel, engineered lipocalin, binding protein, protein binding-protein fibril complex, protein binding/protein fibril
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted : P80188; Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 103140.38

構造登録者

Eichinger, A.,Skerra, A. (登録日: 2013-09-24, 公開日: 2015-08-12, 最終更新日: 2023-09-20)

• 主引用文献: Rauth, S.,Hinz, D.,Borger, M.,Uhrig, M.,Mayhaus, M.,Riemenschneider, M.,Skerra, A.; High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.; Biochem.J., 473:1563-1578, 2016; PubMed: 27029347; DOI: 10.1042/BCJ20160114

実験手法

X-RAY DIFFRACTION (2.3 Å)