4MVI
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Summary for 4MVI
Entry DOI | 10.2210/pdb4mvi/pdb |
Related | 4MVK 4MVL |
Descriptor | Neutrophil gelatinase-associated lipocalin, Beta-amyloid protein 40 (3 entities in total) |
Functional Keywords | beta-barrel, engineered lipocalin, binding protein, binding protein-protein fibril complex, protein binding-protein fibril complex, protein binding/protein fibril |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P80188 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 2 |
Total formula weight | 25869.27 |
Authors | Eichinger, A.,Skerra, A. (deposition date: 2013-09-24, release date: 2015-08-12, Last modification date: 2023-09-20) |
Primary citation | Rauth, S.,Hinz, D.,Borger, M.,Uhrig, M.,Mayhaus, M.,Riemenschneider, M.,Skerra, A. High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473:1563-1578, 2016 Cited by PubMed: 27029347DOI: 10.1042/BCJ20160114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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