4MVH

Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor

4MVH の概要

• エントリーDOI: 10.2210/pdb4mvh/pdb
• 関連するPDBエントリー: 4MUW
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: pde10a, phosphodiesterase 10a, inhibitors, keto-benzimidazoles, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9Y233
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83368.02

構造登録者

Chmait, S.,Jordan, S. (登録日: 2013-09-24, 公開日: 2013-10-23, 最終更新日: 2014-01-15)

• 主引用文献: Hu, E.,Kunz, R.K.,Chen, N.,Rumfelt, S.,Siegmund, A.,Andrews, K.,Chmait, S.,Zhao, S.,Davis, C.,Chen, H.,Lester-Zeiner, D.,Ma, J.,Biorn, C.,Shi, J.,Porter, A.,Treanor, J.,Allen, J.R.; Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).; J.Med.Chem., 56:8781-8792, 2013; PubMed: 24102193; DOI: 10.1021/jm401234w

実験手法

X-RAY DIFFRACTION (2.496 Å)