4MUN
Crystal structure of pantothenate synthetase in complex with 2-(5-methoxy-2-(2-nitro-4-(trifluoromethyl)phenylsulfonylcarbamoyl)-1H-indol-1-yl)acetic acid
Summary for 4MUN
Entry DOI | 10.2210/pdb4mun/pdb |
Related | 4MQ6 4MUE 4MUF 4MUG 4MUH 4MUI 4MUK 4MUL |
Descriptor | Pantothenate synthetase, ETHANOL, [5-methoxy-2-({[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl}carbamoyl)-1H-indol-1-yl]acetic acid, ... (6 entities in total) |
Functional Keywords | alpha beta 3-layer(aba) sandwich rossmann fold, pantoate-ligase, atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 65792.65 |
Authors | Silvestre, H.L.,Blundell, T.L. (deposition date: 2013-09-22, release date: 2014-08-27, Last modification date: 2023-09-20) |
Primary citation | Hung, A.W.,Silvestre, H.L.,Wen, S.,George, G.P.,Boland, J.,Blundell, T.L.,Ciulli, A.,Abell, C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. Chemmedchem, 11:38-42, 2016 Cited by PubMed: 26486566DOI: 10.1002/cmdc.201500414 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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