4MUN
Crystal structure of pantothenate synthetase in complex with 2-(5-methoxy-2-(2-nitro-4-(trifluoromethyl)phenylsulfonylcarbamoyl)-1H-indol-1-yl)acetic acid
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EOH A 401 |
Chain | Residue |
A | THR218 |
B | HIS222 |
B | THR225 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EOH A 402 |
Chain | Residue |
A | ASN176 |
A | HOH617 |
A | HOH734 |
site_id | AC3 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE 2DZ A 403 |
Chain | Residue |
A | HIS44 |
A | GLY46 |
A | HIS47 |
A | GLN72 |
A | TYR82 |
A | HIS135 |
A | LYS160 |
A | ASP161 |
A | GLN164 |
A | PRO185 |
A | THR186 |
A | VAL187 |
A | MET195 |
A | SER196 |
A | SER197 |
A | 2DZ405 |
A | GOL408 |
A | HOH574 |
A | HOH652 |
A | HOH718 |
A | HOH720 |
A | HOH731 |
A | PRO38 |
A | THR39 |
A | MET40 |
site_id | AC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 2DZ A 404 |
Chain | Residue |
A | MET71 |
A | LEU114 |
A | THR117 |
A | PRO133 |
A | THR134 |
A | ALA137 |
A | GLY138 |
A | THR141 |
A | HOH704 |
A | HOH740 |
B | ILE3 |
B | PRO4 |
B | PHE6 |
B | PRO8 |
B | LEU27 |
B | THR30 |
B | ARG32 |
B | GLN119 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 2DZ A 405 |
Chain | Residue |
A | ASP78 |
A | ALA81 |
A | TYR82 |
A | PRO83 |
A | GLU128 |
A | PRO131 |
A | ARG132 |
A | HIS135 |
A | SER197 |
A | ARG198 |
A | TYR201 |
A | ARG278 |
A | 2DZ403 |
A | HOH515 |
A | HOH614 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 406 |
Chain | Residue |
A | MET109 |
A | TYR110 |
A | GLY113 |
A | ARG115 |
A | THR116 |
A | LYS145 |
A | HOH738 |
B | ASP174 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 407 |
Chain | Residue |
A | LEU114 |
A | ARG115 |
A | THR117 |
B | GLN119 |
B | PRO120 |
B | GLY121 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 408 |
Chain | Residue |
A | PRO38 |
A | MET40 |
A | GLN72 |
A | VAL143 |
A | GLN164 |
A | 2DZ403 |
A | HOH585 |
A | HOH716 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 409 |
Chain | Residue |
A | PRO111 |
A | ASP112 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EOH A 410 |
Chain | Residue |
A | ALA205 |
A | GLN206 |
A | ALA209 |
A | PRO243 |
A | GLY244 |
A | HOH619 |
A | HOH748 |
site_id | BC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO A 411 |
Chain | Residue |
A | VAL179 |
A | HOH537 |
A | HOH709 |
B | GLN148 |
B | ARG151 |
A | LEU147 |
A | GLN148 |
A | ARG151 |
A | ASP178 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 412 |
Chain | Residue |
A | ALA21 |
A | SER24 |
A | ARG25 |
A | GLN148 |
A | ILE149 |
A | VAL150 |
A | ARG151 |
B | ASP178 |
site_id | BC4 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE 2DZ B 401 |
Chain | Residue |
B | PRO38 |
B | THR39 |
B | MET40 |
B | HIS44 |
B | GLY46 |
B | HIS47 |
B | HIS135 |
B | VAL139 |
B | VAL143 |
B | PHE157 |
B | LYS160 |
B | ASP161 |
B | GLN164 |
B | PRO185 |
B | THR186 |
B | VAL187 |
B | MET195 |
B | SER196 |
B | SER197 |
B | HOH541 |
B | HOH551 |
B | HOH713 |
B | HOH717 |
B | HOH722 |
B | HOH728 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 402 |
Chain | Residue |
A | ASP174 |
B | MET109 |
B | TYR110 |
B | GLY113 |
B | ARG115 |
B | THR116 |
B | LYS145 |
B | HOH537 |
site_id | BC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 404 |
Chain | Residue |
A | GLN148 |
A | ARG151 |
B | LEU147 |
B | GLN148 |
B | ASP178 |
B | VAL179 |
B | HOH506 |
B | HOH544 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | HIS47 | |
B | HIS47 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16460002 |
Chain | Residue | Details |
A | MET40 | |
A | GLY158 | |
A | VAL187 | |
A | MET195 | |
B | MET40 | |
B | GLY158 | |
B | VAL187 | |
B | MET195 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | GLN72 | |
B | GLN164 | |
A | ASP88 | |
A | ASP89 | |
A | GLN92 | |
A | GLN164 | |
B | GLN72 | |
B | ASP88 | |
B | ASP89 | |
B | GLN92 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 229 |
Chain | Residue | Details |
A | MET40 | electrostatic stabiliser |
A | ARG198 | electrostatic stabiliser, hydrogen bond donor |
A | HIS44 | electrostatic stabiliser, hydrogen bond donor, van der waals interaction |
A | HIS47 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, van der waals interaction |
A | ASP88 | metal ligand |
A | ASP89 | metal ligand |
A | GLN92 | metal ligand |
A | LYS160 | electrostatic stabiliser |
A | SER196 | electrostatic stabiliser, hydrogen bond donor |
A | SER197 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 229 |
Chain | Residue | Details |
B | MET40 | electrostatic stabiliser |
B | ARG198 | electrostatic stabiliser, hydrogen bond donor |
B | HIS44 | electrostatic stabiliser, hydrogen bond donor, van der waals interaction |
B | HIS47 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, van der waals interaction |
B | ASP88 | metal ligand |
B | ASP89 | metal ligand |
B | GLN92 | metal ligand |
B | LYS160 | electrostatic stabiliser |
B | SER196 | electrostatic stabiliser, hydrogen bond donor |
B | SER197 | electrostatic stabiliser, hydrogen bond donor |