4MU3

The form A structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and a mixture of its substrate, 2R3S-IGP, and an inhibitor, 2S3S-IGP, to 1.12 A resolution

4MU3 の概要

• エントリーDOI: 10.2210/pdb4mu3/pdb
• 関連するPDBエントリー: 4MU0 4MU1 4MU2 4MU4
• 分子名称: Imidazoleglycerol-phosphate dehydratase 2, chloroplastic, MANGANESE (II) ION, (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate, ... (6 entities in total)
• 機能のキーワード: hydro-lyase, histidine biosynthesis, manganese binding, chloroplastic, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Arabidopsis thaliana (mouse-ear cress)
• 細胞内の位置: Plastid, chloroplast : O23346
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23286.63

構造登録者

Bisson, C.,Britton, K.L.,Sedelnikova, S.E.,Baker, P.J.,Rice, D.W. (登録日: 2013-09-20, 公開日: 2014-09-24, 最終更新日: 2023-09-20)

• 主引用文献: Bisson, C.,Britton, K.L.,Sedelnikova, S.E.,Rodgers, H.F.,Eadsforth, T.C.,Viner, R.C.,Hawkes, T.R.,Baker, P.J.,Rice, D.W.; Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination.; Structure, 23:1236-1245, 2015; PubMed: 26095028; DOI: 10.1016/j.str.2015.05.012

実験手法

X-RAY DIFFRACTION (1.12 Å)