4MRD

Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule

4MRD の概要

• エントリーDOI: 10.2210/pdb4mrd/pdb
• 関連するPDBエントリー: 4MRE 4MRF 4MRG 4MRH 4NP2 4NP3
• 分子名称: CD44 antigen, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: link module, cell receptor, hyaluronan binding, cell surface, cell adhesion
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P15379
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17483.21

構造登録者

Liu, L.K.,Finzel, B. (登録日: 2013-09-17, 公開日: 2014-04-16, 最終更新日: 2020-07-29)

• 主引用文献: Liu, L.K.,Finzel, B.C.; Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors.; J.Med.Chem., 57:2714-2725, 2014; PubMed: 24606063; DOI: 10.1021/jm5000276

実験手法

X-RAY DIFFRACTION (2.55 Å)